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of transforming, not only pneumococci of different types one into the other, buy inderal but also pneumococci into streptococci, streptococci into pneumococci, and ap- parently repeating this process indefinitely. It is evident that if definite [)roof was brought that such transformations occur frequently, that the trans- formation of one type of pneumococcus into an- other may occur within a short time in the mouth, for instance, such an observation would generic inderal preclude the value of any epidemiological studies based on differences of type, although it would not neces- sarily have any importance in connection with the problem of specific cure. order inderal If such transformations may occur, contact infection may play little role in pneumococcus infection, and the disease may arise because of the transformation of buy propranolol the pneumococcus of the normal mouth into one of the fixed types. From what is known of other biological reactions, however, it propranolol hydrochloride 80 mg for anxiety seems little likely that such transforma- tions occur. Certainly such repeated transforma- tions backward and online propranolol forward are unknown to biol- ogists. Nevertheless, such a possibility is difficult to exclude, just as it is difficult to deny that colon inderal mg bacilli may be transformed into typhoid bacilli. Nothing in our own personal experience, however, suggests such a transformation of one type into an- other, although we have carefully looked for it. We have now studied several inderal price hundred races of pneu- mococci, some of them over a period of three years. Thev have been repeatedly transferred on artificial media and repeatedly passed through animals, some purchase propranolol of them now through as many as a hundred ani- mals, and we have yet to see an example of trans- formation. Thev al'wavs breed true. An organism COLE: I'NEUMOCOCCUS INFECTION. (N'f.w inderal online York Medical Journai.. of inderal cost Type I remains Type i and an organism of Type n remains Type ii. Certainly after infection has occurred, such changes do not take place in the body, at least with any frequency. Cultures are frequently made every day from our cases of pneun)onia. Also in certain late complications, such as empyema or joint infec- tion, cultures have been made frequently, and in no case have we found at one time one type of organ- ism and at purchase inderal another time another type of organism. Doctor Chickcring^ has also made a study of the agglutinins present in the blood of patients suffer- ing from pneumonia. Agglutinins in the nonfatal cases usually buy cheap inderal appear about the time of crisis. They disappear after two or three weeks except in the cases sufifering from complications such as delayed resolution or empyema. In such cases the agglu- tinins may ])ersist for a long time, even several months. In none of the cases, however, have ag- glutinins ever been present for any type of organism except that isolated from the infected patient. In case of infection with an organism of Group iv only the homologous strain has been agglutinated. I'ntil we have more definite evidence of trans- formation, therefore, it does purchase inderal online not seem necessary to take it into too serious account in our consideration of the epidemiology of pneumonia. It is probable that we shall find that in pneumonia the same gen- eral principles govern as in the case of tj'phoid and other infectious diseases. NATURE OF THK INTOXICATION. It is now known that bacteria growing on the surface of the body, or in cavities communicating with the external world, or even growing in the blood and tissues, do not necessarily cause death or even give rise to marked symptoms. For instance, rabbits, and even man, may act as carriers of Bacillus typhosus for months, without exhibiting harmful effects. To gain any conception of the nature of the general manifestations of the disease pneumonia, therefore, we must learn more of the manner in which the pathological symptoms are brought about than merely recognizing that living bacteria are present. As is well known, bacteria like diphtheria and tetanus bacilli produce 'their effects by a poison which is produced in cheap inderal the body when the bacteria grow there and carry on their metabolic activities. These poisons are not only produced in inderal tablets the animal body, but also are formed when the bacteria grow outside the body in a suitable culture medium. In the case of purchase propranolol online pneumococci and many other bacteria, this production of a poison outside the body does not occur. buy inderal online This fact, however, does not exclude the possibility that they do produce such a poison when growing within the body, and that to this poison the pathological and functional changes are due. The efforts to detect this poison in the in- fected animal, however, have been just as unavail- ing. The blood and body fluids apparently do not contain such a poison. order inderal online Up to the present time,

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